ea0070aep1002 | Hot topics (including COVID-19) | ECE2020
Fruehbuss Laura
, Meng Yao
, Sun Jing
, Gonzalez Marques Jair
, Koletzko Berthold
, Mederos Y Schnitzler Michael
, Gudermann Thomas
, Beuschlein Felix
, Ann Williams Tracy
, Heinrich Daniel
, Adolf Christian
, Reincke Martin
, Schneider Holger
Rationale: Endothelial dysfunction (ED) is a hallmark of primary aldosteronism and paves the way for subsequent atherosclerotic disease. Past research has confirmed that one factor involved in ED is disturbed nitric oxide (NO) signalling. Since defects in NO release alone cannot explain the whole effect, we set out to address the role of endothelial CYP-expoygenase products (epoxyeicosatrienoic acids, EETs) in aldosterone-mediated endothelial dysfunction.<p class="abstext"...